Mahalo - Jason Calacanis’ baby, a very serious contender with lots of funding, is best described as a cross between Wikipedia and Google. If a human edit result for your query doesn’t exist, you’ll be transfered to standard Google results.

Dmoz - Probably the most popular and largest human edited search engine directory. All sites must be submitted and approved for placement in the directory.

Sproose – A user powered search engine. Users vote on the results and then the sites are ranked accordingly. This allows them to provide quality results, without all of the junk that you find in a typical search engine.

Directory Hound – Human edited directory modeled after Dmoz. All sites must be submitted and approved before entry. Covers all general categories.

Yoofindit.com – General information directory, all sites are reviewed by staff members.

Best of the Web – Very popular directory, with strict submission guidelines. Also have an award program for the best ranked sites.
10 Directory - Nice, clean looking categorized web directory.

Ajdee.com – All submitted sites are reviewed and approved by editors before inclusion is granted. They cover all general categories and do not allow adult related websites.

Search Turtle – A human edited web directory and search engine. Make claims of having the most rigorous submission guidelines, to allow for the best spam-free results.

GoGuides.org – Community guides review all site submissions for inclusion within the directory. Very clean look, easy to use.

JoeAnt – A very large directory portal operated by volunteer guides. You can find a little bit of everything here and you can apply to become a guide yourself.

ChaCha – Suppose you can’t find what you are searching for. One click on ChaCha will get you in touch with a live guide to help you find what you want.